Introduction

Acute coronary syndrome (ACS) continues to be a substantial contributor to both morbidity and mortality, withstanding notable evolutions in its prevention and treatment. (1).

Hypercholesterolemia is a known significant risk factor for coronary artery disease. Increased total cholesterol, LDL cholesterol (LDL-C), and non-HDL-Cholesterol (non-HDL-C) are associated with 20 – 30% risk of premature cardiac damage in youth. Hypertriglyceridemia is associated with two-threefold risk of incident and progressive cardiac and structural damage. (1) Lipid-lowering therapy must be initiated immediately after ACS to reduce the risk of recurrent cardiovascular events and mortality. (2) The approach to managing hypercholesterolemia has evolved significantly over the years, emphasizing the need for an aggressive treatment, akin to firing at a target, while also highlighting the importance of long-term vigilance.