• 2025 European Society of Cardiology (ESC ) guidelines include a new Class IIa recommendation for considering intervention in asymptomatic patients with severe aortic stenosis, if the procedural risk is low.
• This recommendation is based on four trials comparing early intervention to conservative management in this patient group.
• Positive outcomes in these trials were driven mainly by a reduction in unplanned hospitalisations rather than mortality. A meta-analysis also demonstrated a reduction in stroke in the early intervention group.
• The studies were heterogenous and included several design limitations that have been explored in critical reviews. There is also a lack of data regarding patient selection for early intervention.
Author Sub-editor: Dr Tha Htet Nyi Dr Tha Htet Nyi is a cardiology registrar in South London Deanery with subspecialty interests in multimodal cardiac imaging and
Author Sub-editor: Dr Chi Ho Fung Dr Chi Ho Fung graduated with Distinction from Imperial College School of Medicine in 2019 with an Intercalated Bachelor
Authors Heartbeat Sub-Editor: Alexandar Drampalou I am Dr.Alexandar Drampalou ,a cardiologist currently specializing in cardiac magnetic resonance (CMR) at Guy’s and St Thomas’ Hospital and
Authors Heartbeat Sub-Editor: Marina Zafeiri Dr Marina Zafeiri is an IMT3 in the Wessex deanery, with a strong interest in Cardiology. She graduated from Athens
Author Sub-editor: Dr May Hu Dr May Hu is a cardiology trainee in the North West deanery. She graduated with First Class Honours from the University
