Transcatheter aortic valve implantation and its under-estimated  coronary artery disease (CAD) risk

Khin Kay Kay Kyaw
21/05/2025

Take home messages

  • Coronary artery Disease (CAD) is the is leading cause of mortality among patients with aortic stenosis (AS) following transcatheter aortic valve implantation (TAVI)
  • Prevalence of CAD post-TAVI:  its estimated prevalence is at >70 % in high-risk elderly patients due to shared common pathogenetic factors, or procedural related hemodynamic risks, following transcatheter aortic valve implantation (TAVI)
  • Evaluation of CAD risk : Potential role of pre-procedural evaluation of coronary obstruction  and its future challenges of revascularization  is important for CVS risk prevention following TAVI (14,15)
  • Future primary research is warranted to establish new recommendations for unexplained CAD risks and its management to reduce in-hospital procedural or patient-related outcomes following TAVI.

Coronary artery disease (CAD) is the leading cause of mortality among aortic stenosis  (AS) patient populations due to common pathogenetic factors such as ageing, atherosclerotic plaques, multi-morbid risks including diabetes, hypertension and dyslipidaemia, or procedural related coronary access obstruction, with the revolution of transcatheter aortic valve implantation  (TAVI). (1) The prevalence of atherosclerotic cardiovascular disease (ASCVD) post TAVI aortic stenotic individuals has become an increasing trend, but its evidence remains debated. (15)